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Biochemistry 63:4005
BIOCHEMICAL REGULATION
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Instructor: Dr. Ken Storey |
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Room: 507 Steacie Building |
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Phone: 520-3678 |
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OFFICE HOURS – 1 hour after each
class |
Prerequisite: Biochemistry 63.3100
All living organisms possess
inherent flexibility in their metabolic make-up that permits them to respond
appropriately to energy demands (e.g. for growth, reproduction, physiological
activities), nutrient availability, and environmental stresses. Along with this
flexibility, a series of rigorous control mechanisms, operating at the
molecular level of biological organization, have evolved. This due approach,
combining flexibility and stringent regulation, provides for efficient
programming of cell survival and growth, ultimately ensuring the maintenance of
cell homeostasis. The purpose of this course is to examine and discuss the
molecular mechanisms of metabolic regulation.
This course builds on the
basic knowledge of metabolic control that you acquired in Biochemistry 3100.
You have learned the names and structures of biological molecules and some of
their functions. You will build on this knowledge of the functions or
macromolecules and pathways to study the mechanisms for control and integration
of metabolism. Topics will include methodologies used to study metabolism,
theories of transcriptional and translational controls, signal transduction and
hormonal regulation, and the effect of environment on metabolism.
A. "Fine Control" : Regulation
of enzyme and pathway activity at the posttranslational level
B. "Coarse Control" : Regulation
of the processes of transcription, translation and protein degradation.
Metabolic regulation of
catabolism and anabolism will be discussed including regulation of enzymes,
roles of carbohydrate and fatty acid fuels, and oxidative metabolism. The role
of compartmentation in metabolism and tissue
interactions in metabolic control will be investigated.
COURSE STRUCTURE: I will lecture for the first part of the
course covering the basics. You will then individually study and present to the
class various individual topics in metabolic regulation. The course is not meant to tell you
everything about all aspects of metabolic control. But, once you have learned
to tackle selected areas in depth, you can use the general approaches learned
to explore any other area of metabolism that you tackle in the future.
COURSE EVALUATION:
|
|
%
of Final Grade |
|
Analysis of a
primary-literature paper (A. written) |
10 |
|
Analysis of a primary
literature paper (B. oral) |
10 |
|
Seminar on Selected Topic |
35 |
|
NSERC-like Grant Proposal |
40 |
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Class Participation |
5 |
ASSIGNMENTS
1. Oral and written critiques of journal articles
LECTURES AS PDF FILES
Access
to the LECTURE files is Password Protected and available only to students in
the class.
Click
here go to the INDEX of lectures. User name is 4005.
Password was provided in class.
CHAPTERS TO READ
These
are all PDF files ranging from 200 KB to 2 MB.
Access
to the chapters is Password Protected and available only to students in the
class.
Click
here go to the INDEX of chapters. User name is 4005.
Password was provided in class.
LITERATURE SEARCHING:
List
of Journals,
Books and Serial Books at the CISTI library relevant to metabolic regulation
Link to CISTI catalogue (or link via Carleton's library site if you want to order papers)
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